順天堂大學(xué)醫(yī)學(xué)部附屬順天堂醫(yī)院 泌尿器科

專(zhuān)業(yè)領(lǐng)域

泌尿器外科手術(shù)、達(dá)芬奇機(jī)器人輔助手術(shù)(前列腺?腎臟?膀胱)

進(jìn)展期腎癌?膀胱癌的根治手術(shù)、腸代膀胱術(shù)、尿道外傷重建術(shù)

泌尿腫瘤的化療、多發(fā)性腎囊腫治療、男性問(wèn)題(ED、男性更年期障礙、LOH綜合征)

醫(yī)生履歷

1985年?yáng)|京大學(xué)醫(yī)學(xué)部醫(yī)學(xué)系 畢業(yè)

1985年?yáng)|京大學(xué)醫(yī)學(xué)部附屬醫(yī)院急救部 研修醫(yī)

1986年?yáng)|京大學(xué)醫(yī)學(xué)部附屬醫(yī)院泌尿科 助手

1988年~1991年美國(guó)德克薩斯大學(xué) 研究員(腎臟學(xué)、移植醫(yī)療)

1995年國(guó)立癌癥中心中央醫(yī)院泌尿科

1998年?yáng)|京大學(xué)醫(yī)學(xué)部 講師

2002年杏林大學(xué)醫(yī)學(xué)部泌尿科研究室 助教授

2003年帝京大學(xué)醫(yī)學(xué)部泌尿科研究室 主任教授

2012年~至今順天堂大學(xué)研究生院醫(yī)學(xué)系研究泌尿外科研究室 教授

認(rèn)證資格及所屬學(xué)會(huì)

【資格】

?Permanent Certificate Educational Commission of Foreign Medical Graduates, The United States of America.

?日本泌尿器科學(xué)會(huì) 【指導(dǎo)醫(yī)】

?日本腎臟學(xué)會(huì) 【指導(dǎo)醫(yī)】

?泌尿器腹腔鏡技術(shù)認(rèn)定醫(yī)

【公職委員】

?厚生勞動(dòng)省 醫(yī)生考核委員

?醫(yī)道審議會(huì) 醫(yī)生分科會(huì)專(zhuān)門(mén)委員

?保健醫(yī)療專(zhuān)門(mén)審查員

?文部科學(xué)省　大學(xué)設(shè)置?學(xué)校法人審議會(huì)專(zhuān)門(mén)委員(大學(xué)設(shè)置分科會(huì))

?千葉縣　健康千葉地域?職域聯(lián)合推進(jìn)協(xié)議會(huì)　委員

?日本學(xué)術(shù)振興會(huì)科學(xué)研究費(fèi)委員會(huì)專(zhuān)門(mén)委員

?財(cái)団法人日本腎臟財(cái)團(tuán)　CKD対策推進(jìn)委員會(huì)委員

?日本醫(yī)生協(xié)會(huì) 醫(yī)生賠償保險(xiǎn)調(diào)查委員會(huì)專(zhuān)門(mén)委員 等

【所屬學(xué)會(huì)】

?亞洲太平洋前立腺學(xué)會(huì) 【理事長(zhǎng)】

?日本Men's Health醫(yī)學(xué)會(huì) 【理事長(zhǎng)】

?日本泌尿器科學(xué)會(huì)

?日本腎臟學(xué)會(huì)

?日本癌癥學(xué)會(huì)

?日本癌癥治療學(xué)會(huì)

?日本內(nèi)窺鏡外科學(xué)會(huì)

?日本性功能學(xué)會(huì)

?日本抗衰老醫(yī)學(xué)會(huì) 等

獲獎(jiǎng)、著作及論文

【獲獎(jiǎng)】

?第3回　日本泌尿器科學(xué)會(huì)賞平成7年4月

?First Prize in Research, 1991 Research Fellow Contest, Fellowship Program. National Kidney Foundation/American Society of Nephrology.

?ベストプロフェッサー賞　平成26年度　順天堂大學(xué)醫(yī)學(xué)部

【著作】

?標(biāo)準(zhǔn)泌尿器科學(xué)　編集　醫(yī)學(xué)書(shū)院

?今日の治療薬?分擔(dān)?南江堂

?今日の治療指針?分擔(dān)?醫(yī)學(xué)書(shū)院

?ホルモン力が人生を変える (小學(xué)館101新書(shū) 23)

?男性の病気の手術(shù)と治療―診察室では聞けない前立腺?ED?がんの心得 (おとなのための醫(yī)學(xué)読本)かまくら春秋社

?ヤル気がでる! 最強(qiáng)の男性醫(yī)療 (文春新書(shū) 919)

【論文】

主要原著論文

1. Horie S, Moe O, Tejedor A, Alpern RJ : Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 87:4742-4745, 1990

2. Horie S, Moe O, Miller RT, Alpern RJ: Long-term activation of protein kinase C causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. The Journal of Clinical Investigation 89: 365-372, 1992

3. Benjamin I, Horie S, Greenberg ML, Alpern RJ, Williams RS: Induction of stress proteins cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. The Journal of Clinical Investigation 89:1685-1689, 1992

4. Horie S, Moe O, Yamaji Y, Cano A, Miller RT, Alpern RJ: Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. Proceedings of the National Academy of Sciences of the United States of America. 89:5236-5240, 1992

5. Horie S, Higashihara E, Nutahara K, Mikami, Okubo A, Kano M, Kawabe K: Mediation of renal cyst formation by hepatocyte growth factor. Lancet 344: 789-791, 1994

6. Horie S, Kano M, Higashihara E, Moriyama N, Tanaka E, Hirose A, Kakizoe T, Kawabe K : Expression of Fas in renal cell carcinoma. Japanese Journal of Clinical Oncology 27:384-388, 1997

7. Horie S, Tobisu K, Fujimoto H, Doi N, Kakizoe T : Urinary incontinence following non nerve-spared radical prostatectomy with neoadjuvant androgen deprivation. Urology 53:561-567, 1999

8. Horie S, Aruga S, Kawamata S, Okui N, Kakizoe T, Kitamura T : Biological role of HGF/MET pathway in renal cell carcinoma. The Journal of Urology 161:990-997, 1999

9. Muto S, Horie S, Takahashi S, Tomita K, and Kitamura T : Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Research 60:4021-4025, 2000

10. Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S : Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Human Molecular Genetics 11:1731-1742, 2002

11. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, Horie S : Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. Journal of the National Cancer Institute 97:1734-46, 2005

12. Horie S. ADPKD: molecular characterization and quest for treatment. Clinical and Experimental Nephrology 9:282-291, 2005

13. Horie S. Symptoms and Treatment of Andropause. The Japan Medical Association Journal 49:382-384, 2006

14. Muto S, Katsuki M, Horie S : Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis. Cancer Science 97:842-847, 2006

15. Muto S, Katsuki M, Horie S: Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice. Cancer Science 98:1549-1556, 2007

16. Muto S, Kamiyama Y, Ide H, Okada H, Saito K, Nishio K, Tokiwa S, Kaminaga T, Furui S, Horie S: Real-time MRI of Orthotopic ileal neobladder voiding: preliminary findings. European Urology 53:363–369, 2008

17. Yasuda M, Ide H, Furuya K, Yoshii T, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Horie S. Salivary 8-OHdG: a useful biomarker for predicting severe ED and hypogonadism. Journal of Sexual Medicine 5:1482-91, 2008.

18. Ide H, Yu J, Lu Y, China T, Kumamoto T, Koseki T, Muto S, Horie S. Testosterone augments polyphenol-induced DNA damage response in prostate cancer cell line, LNCaP. Cancer Sci. 2011 Feb;102(2):468-71.

19. Horie S, Ito S, Okada H, Kikuchi H, Narita I, Nishiyama T, Hasegawa T, Mikami H, Yamagata K, Yuno T, Muto S. Japanese guidelines of the management of hematuria 2013. Clin Exp Nephrol. 2014 Oct;18(5):679-89.

20. Muto S, Kawano H, Higashihara E, Narita I, Ubara Y, Matsuzaki T, Ouyang J, Torres VE, Horie S. The effect of tolvaptan on autosomal dominant polycystic kidney disease patients: a subgroup analysis of the Japanese patient subset from TEMPO 3:4 trial. Clin Exp Nephrol. 2015 Feb 7. [Epub ahead of print]

21. Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; Conference Participants. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2015 Jul;88(1):17-27.